4I75

Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with the NiTris metalorganic complex

Summary for 4I75

• Entry DOI: 10.2210/pdb4i75/pdb
• Related: 3EPW 3FZ0 4I70 4I71 4I72 4I73 4I74
• Descriptor: Inosine-adenosine-guanosine-nucleoside hydrolase, CALCIUM ION, NICKEL (II) ION, ... (5 entities in total)
• Functional Keywords: nucleoside hydrolase, open (alpha, beta) structure, nh fold, hydrolase
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 2
• Total formula weight: 73554.27

Authors

Giannese, F.,Degano, M. (deposition date: 2012-11-30, release date: 2013-08-07, Last modification date: 2024-04-03)

• Primary citation: Giannese, F.,Berg, M.,Van der Veken, P.,Castagna, V.,Tornaghi, P.,Augustyns, K.,Degano, M.; Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor; Acta Crystallogr.,Sect.D, 69:1553-1566, 2013; PubMed: 23897478; DOI: 10.1107/S0907444913010792

Experimental method

X-RAY DIFFRACTION (1.8 Å)