4I75
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with the NiTris metalorganic complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006152 | biological_process | purine nucleoside catabolic process |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0008477 | molecular_function | purine nucleosidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| A | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| A | 0020015 | cellular_component | glycosome |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006152 | biological_process | purine nucleoside catabolic process |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0008477 | molecular_function | purine nucleosidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| B | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| B | 0020015 | cellular_component | glycosome |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 401 |
| Chain | Residue |
| A | ASP10 |
| A | ASP15 |
| A | THR137 |
| A | ASP261 |
| A | TRS403 |
| A | HOH521 |
| A | HOH697 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 402 |
| Chain | Residue |
| A | TRS403 |
| A | HOH697 |
| A | HOH698 |
| A | ASP14 |
| A | ASP40 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TRS A 403 |
| Chain | Residue |
| A | ASP14 |
| A | ASP40 |
| A | PHE79 |
| A | MET164 |
| A | ASN173 |
| A | GLU184 |
| A | TRP185 |
| A | TRP260 |
| A | ASP261 |
| A | CA401 |
| A | NI402 |
| A | HOH521 |
| A | HOH697 |
| A | HOH698 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI A 404 |
| Chain | Residue |
| A | GLY-2 |
| A | SER-1 |
| A | HIS0 |
| A | ARG204 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 405 |
| Chain | Residue |
| A | HIS115 |
| A | HOH700 |
| A | HOH704 |
| A | HOH712 |
| A | HOH744 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NI A 406 |
| Chain | Residue |
| A | HIS317 |
| A | HOH681 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TRS B 401 |
| Chain | Residue |
| A | HIS58 |
| A | LEU65 |
| A | THR81 |
| A | GLU82 |
| A | HOH577 |
| A | HOH638 |
| B | ILE250 |
| B | LEU251 |
| B | ASP253 |
| B | NI405 |
| B | HOH700 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TRS B 402 |
| Chain | Residue |
| A | ILE250 |
| A | ASP253 |
| B | HIS58 |
| B | THR81 |
| B | GLU82 |
| B | LEU104 |
| B | TRS403 |
| B | NI404 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE TRS B 403 |
| Chain | Residue |
| A | ASP253 |
| B | HIS58 |
| B | LYS62 |
| B | TRS402 |
| B | NI404 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI B 404 |
| Chain | Residue |
| A | ASP253 |
| B | HIS58 |
| B | TRS402 |
| B | TRS403 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI B 405 |
| Chain | Residue |
| A | HIS58 |
| B | ASP253 |
| B | TRS401 |
| B | HOH700 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI B 406 |
| Chain | Residue |
| B | HIS115 |
| B | HOH709 |
| B | HOH710 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI B 407 |
| Chain | Residue |
| A | HOH635 |
| B | HIS317 |
| B | HOH707 |
| B | HOH708 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 408 |
| Chain | Residue |
| B | ASP10 |
| B | ASP15 |
| B | THR137 |
| B | ASP261 |
| B | TRS410 |
| B | HOH507 |
| B | HOH699 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI B 409 |
| Chain | Residue |
| B | ASP14 |
| B | ASP40 |
| B | TRS410 |
| B | HOH698 |
| B | HOH699 |
| site_id | BC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TRS B 410 |
| Chain | Residue |
| B | HOH507 |
| B | HOH698 |
| B | HOH699 |
| B | HOH725 |
| B | ASP14 |
| B | ASP40 |
| B | PHE79 |
| B | MET164 |
| B | ASN173 |
| B | GLU184 |
| B | TRP185 |
| B | TRP260 |
| B | ASP261 |
| B | CA408 |
| B | NI409 |
