4I4B

HMG-CoA Reductase from Pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of HMG-CoA

Summary for 4I4B

• Entry DOI: 10.2210/pdb4i4b/pdb
• Related: 1QAX 1QAY 1R31 1R71 1T02 4I56 4I64 4I6A 4I6W 4I6Y
• Descriptor: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R,9R,19R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-sulfanyl-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, GLYCEROL, ... (7 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Pseudomonas mevalonii
• Total number of polymer chains: 2
• Total formula weight: 93412.22

Authors

Stauffacher, C.V.,Steussy, C.N.,Critchelow, C.J.,Schmidt, T.,Min, J.,Wrensford, L.V.,Burgner, J.W.,Rodwell, V.W. (deposition date: 2012-11-27, release date: 2013-07-17, Last modification date: 2024-02-28)

• Primary citation: Steussy, C.N.,Critchelow, C.J.,Schmidt, T.,Min, J.K.,Wrensford, L.V.,Burgner, J.W.,Rodwell, V.W.,Stauffacher, C.V.; A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.; Biochemistry, 52:5195-5205, 2013; PubMed: 23802607; DOI: 10.1021/bi400335g

Experimental method

X-RAY DIFFRACTION (1.7 Å)