4I4B

HMG-CoA Reductase from Pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of HMG-CoA

4I4B の概要

• エントリーDOI: 10.2210/pdb4i4b/pdb
• 関連するPDBエントリー: 1QAX 1QAY 1R31 1R71 1T02 4I56 4I64 4I6A 4I6W 4I6Y
• 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R,9R,19R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-sulfanyl-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Pseudomonas mevalonii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 93412.22

構造登録者

Stauffacher, C.V.,Steussy, C.N.,Critchelow, C.J.,Schmidt, T.,Min, J.,Wrensford, L.V.,Burgner, J.W.,Rodwell, V.W. (登録日: 2012-11-27, 公開日: 2013-07-17, 最終更新日: 2024-02-28)

• 主引用文献: Steussy, C.N.,Critchelow, C.J.,Schmidt, T.,Min, J.K.,Wrensford, L.V.,Burgner, J.W.,Rodwell, V.W.,Stauffacher, C.V.; A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.; Biochemistry, 52:5195-5205, 2013; PubMed: 23802607; DOI: 10.1021/bi400335g

実験手法

X-RAY DIFFRACTION (1.7 Å)