4I2X

Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117

4I2X の概要

• エントリーDOI: 10.2210/pdb4i2x/pdb
• 分子名称: FabOX117 light chain, FabOX117 heavy chain, Signal-regulatory protein gamma, ... (7 entities in total)
• 機能のキーワード: protein-fab complex, structural genomics, oxford protein production facility, oppf, signal regulatory protein, cd47, cell surface, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 170595.01

構造登録者

Nettleship, J.E.,Ren, J.,Stuart, D.I.,Owens, R.J.,Oxford Protein Production Facility (OPPF) (登録日: 2012-11-23, 公開日: 2013-12-18, 最終更新日: 2024-11-20)

主引用文献

Nettleship, J.E.,Ren, J.,Scott, D.J.,Rahman, N.,Hatherley, D.,Zhao, Y.,Stuart, D.I.,Barclay, A.N.,Owens, R.J.
Crystal structure of signal regulatory protein gamma (SIRP gamma) in complex with an antibody Fab fragment.
Bmc Struct.Biol., 13:13-13, 2013

PubMed Abstract: Signal Regulatory Protein γ (SIRPγ) is a member of a closely related family of three cell surface receptors implicated in modulating immune/inflammatory responses. SIRPγ is expressed on T lymphocytes where it appears to be involved in the integrin-independent adhesion of lymphocytes to antigen-presenting cells. Here we describe the first full length structure of the extracellular region of human SIRPγ.

PubMed: 23826770
DOI: 10.1186/1472-6807-13-13

実験手法

X-RAY DIFFRACTION (2.48 Å)