4I23

Crystal structure of the wild-type EGFR kinase domain in complex with dacomitinib (soaked)

Summary for 4I23

Entry DOI	10.2210/pdb4i23/pdb
Related	4I1Z 4I20 4I21 4I22 4I24
Descriptor	Epidermal growth factor receptor, (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide (2 entities in total)
Functional Keywords	kinase domain, phosphotransfer, atp binding, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	37918.20
Authors	Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Stewart, A. (deposition date: 2012-11-21, release date: 2013-01-16, Last modification date: 2024-02-28)
Primary citation	Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Weinrich, S.,Kath, J.C.,Stewart, A. Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21:209-219, 2013 Cited by PubMed: 23273428 DOI: 10.1016/j.str.2012.11.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation