4I23
Crystal structure of the wild-type EGFR kinase domain in complex with dacomitinib (soaked)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 329 | 37448.3 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | non-polymer | 469.9 | 1 | Chemie (1C9) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 694 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37448.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 469.9 | |
| All* | Total formula weight | 37918.2 |
