4I00

Crystal structure of influenza A neuraminidase N3-H274Y complexed with zanamivir

Summary for 4I00

• Entry DOI: 10.2210/pdb4i00/pdb
• Related: 3CKZ 4HZV 4HZW 4HZX 4HZY 4IZZ
• Descriptor: Neuraminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: neuraminidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus
• Cellular location: Host apical cell membrane ; Single-pass type II membrane protein : A9YN63
• Total number of polymer chains: 1
• Total formula weight: 44906.26

Authors

Li, Q.,Qi, J.,Vavricka, C.J.,Gao, G.F. (deposition date: 2012-11-16, release date: 2013-11-13, Last modification date: 2023-11-08)

• Primary citation: Li, Q.,Qi, J.,Wu, Y.,Kiyota, H.,Tanaka, K.,Suhara, Y.,Ohrui, H.,Suzuki, Y.,Vavricka, C.J.,Gao, G.F.; Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.; J.Virol., 87:10016-10024, 2013; PubMed: 23824808; DOI: 10.1128/JVI.01129-13

Experimental method

X-RAY DIFFRACTION (1.6 Å)