4I00
Crystal structure of influenza A neuraminidase N3-H274Y complexed with zanamivir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Neuraminidase | polymer | 388 | 43352.7 | 1 | UniProt (A9YN63) Pfam (PF00064) | Influenza A virus | |
| 2 | B, C (B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
| 3 | D, E (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | F (A) | ZANAMIVIR | non-polymer | 332.3 | 1 | Chemie (ZMR) | |||
| 5 | G (A) | water | water | 18.0 | 409 | Chemie (HOH) |
Sequence modifications
A: 83 - 469 (UniProt: A9YN63)
| PDB | External Database | Details |
|---|---|---|
| Phe 82 | - | expression tag |
| Tyr 274 | His 276 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43352.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1141.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 412.5 | |
| All* | Total formula weight | 44906.3 |
