4HZM

Crystal structure of Salmonella typhimurium family 3 glycoside hydrolase (NagZ) bound to N-[(3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]butanamide

Summary for 4HZM

Entry DOI	10.2210/pdb4hzm/pdb
Related	4GVF 4GVG 4GVH 4GVI
Descriptor	Beta-hexosaminidase, N-[(3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]butanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	tim-barrel, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Salmonella enterica subsp. enterica serovar Typhimurium
Cellular location	Cytoplasm (By similarity): Q8ZQ06
Total number of polymer chains	2
Total formula weight	78107.66
Authors	Bacik, J.P.,Mark, B.L. (deposition date: 2012-11-15, release date: 2013-06-19, Last modification date: 2023-09-20)
Primary citation	Stubbs, K.A.,Bacik, J.P.,Perley-Robertson, G.E.,Whitworth, G.E.,Gloster, T.M.,Vocadlo, D.J.,Mark, B.L. The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to beta-Lactams. Chembiochem, 14:1973-1981, 2013 Cited by PubMed: 24009110 DOI: 10.1002/cbic.201300395 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation