4GVH

Crystal structure of Salmonella typhimurium family 3 glycoside hydrolase (NagZ) covalently bound to 5-fluoro-GlcNAc.

Summary for 4GVH

Entry DOI	10.2210/pdb4gvh/pdb
Related	4GVF 4GVG 4GVI
Descriptor	Beta-hexosaminidase, 5-fluoro-N-acetyl-alpha-D-glucosamine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	tim-barrel, hydrolase, 5-f-glcnac, hydrolase-substrate complex, hydrolase/substrate
Biological source	Salmonella enterica subsp. enterica serovar Typhimurium
Cellular location	Cytoplasm (By similarity): Q8ZQ06
Total number of polymer chains	2
Total formula weight	78121.50
Authors	Bacik, J.P.,Mark, B.L. (deposition date: 2012-08-30, release date: 2012-12-19, Last modification date: 2020-07-29)
Primary citation	Bacik, J.P.,Whitworth, G.E.,Stubbs, K.A.,Vocadlo, D.J.,Mark, B.L. Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion. Chem.Biol., 19:1471-1482, 2012 Cited by PubMed: 23177201 DOI: 10.1016/j.chembiol.2012.09.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation