4HYM

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

4HYM の概要

• エントリーDOI: 10.2210/pdb4hym/pdb
• 関連するPDBエントリー: 4GEE 4GFN 4GGL 4HXZ 4HY1 4HYP 4HZ0 4HZ5
• 分子名称: Topoisomerase IV, subunit B, 7-({4-[(3R)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)pyrido[2,3-b]pyrazin-2(1H)-one (3 entities in total)
• 機能のキーワード: atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• 由来する生物種: Francisella tularensis subsp. holarctica LVS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 88344.46

構造登録者

Bensen, D.C.,Creighton, C.J.,Kwan, B.,Tari, L.W. (登録日: 2012-11-13, 公開日: 2013-02-13, 最終更新日: 2024-02-28)

• 主引用文献: Tari, L.W.,Trzoss, M.,Bensen, D.C.,Li, X.,Chen, Z.,Lam, T.,Zhang, J.,Creighton, C.J.,Cunningham, M.L.,Kwan, B.,Stidham, M.,Shaw, K.J.,Lightstone, F.C.,Wong, S.E.,Nguyen, T.B.,Nix, J.,Finn, J.; Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.; Bioorg.Med.Chem.Lett., 23:1529-1536, 2013; PubMed: 23352267; DOI: 10.1016/j.bmcl.2012.11.032

実験手法

X-RAY DIFFRACTION (1.9 Å)