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4HW7

Crystal structure of FMS kinase domain with a small molecular inhibitor, PLX647-OME

Summary for 4HW7
Entry DOI10.2210/pdb4hw7/pdb
DescriptorMacrophage colony-stimulating factor 1 receptor, 5-[(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[4-(trifluoromethyl)benzyl]pyridin-2-amine (2 entities in total)
Functional Keywordscsf-1-r, fms proto-oncogene, c-fms, cd115 antigen, kinase, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein: P07333
Total number of polymer chains1
Total formula weight39052.58
Authors
Zhang, Y.,Zhang, C. (deposition date: 2012-11-07, release date: 2013-03-27, Last modification date: 2024-02-28)
Primary citationZhang, C.,Ibrahim, P.N.,Zhang, J.,Burton, E.A.,Habets, G.,Zhang, Y.,Powell, B.,West, B.L.,Matusow, B.,Tsang, G.,Shellooe, R.,Carias, H.,Nguyen, H.,Marimuthu, A.,Zhang, K.Y.,Oh, A.,Bremer, R.,Hurt, C.R.,Artis, D.R.,Wu, G.,Nespi, M.,Spevak, W.,Lin, P.,Nolop, K.,Hirth, P.,Tesch, G.H.,Bollag, G.
Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
Proc.Natl.Acad.Sci.USA, 110:5689-5694, 2013
Cited by
PubMed: 23493555
DOI: 10.1073/pnas.1219457110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9001 Å)
Structure validation

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