4HT1

Human TWEAK in complex with the Fab fragment of a neutralizing antibody

4HT1 の概要

• エントリーDOI: 10.2210/pdb4ht1/pdb
• 分子名称: Tumor necrosis factor ligand superfamily member 12, chimeric antibody Fab, ... (4 entities in total)
• 機能のキーワード: antibody fab, tnf homology domain, cytokine, tweak receptor, membrane bound, extracellular thd domain, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted. Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein: O43508
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 64801.81

構造登録者

Lammens, A. (登録日: 2012-10-31, 公開日: 2013-06-12, 最終更新日: 2017-11-15)

• 主引用文献: Lammens, A.,Baehner, M.,Kohnert, U.,Niewoehner, J.,von Proff, L.,Schraeml, M.,Lammens, K.,Hopfner, K.P.; Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding.; Plos One, 8:e62697-e62697, 2013; PubMed: 23667509; DOI: 10.1371/journal.pone.0062697

実験手法

X-RAY DIFFRACTION (2.498 Å)