4HHF

Crystal Structure of chemically synthesized scorpion alpha-toxin OD1

4HHF の概要

• エントリーDOI: 10.2210/pdb4hhf/pdb
• 分子名称: Alpha-toxin OD1, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total)
• 機能のキーワード: scorpion long-chain alpha-toxin, gating modulator, voltage-gated sodium channels 1.4, 1.6, 1.7, inhibition of fast channel inactivation, c-terminally amidated, venom gland, toxin
• 由来する生物種: Odontobuthus doriae (Yellow Iranian scorpion)
• 細胞内の位置: Secreted: P84646
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7575.71

構造登録者

Wang, C.I.A.,Lewis, R.J.,Alewood, P.F.,Durek, T. (登録日: 2012-10-09, 公開日: 2013-04-24, 最終更新日: 2023-09-20)

• 主引用文献: Durek, T.,Vetter, I.,Wang, C.I.,Motin, L.,Knapp, O.,Adams, D.J.,Lewis, R.J.,Alewood, P.F.; Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1.; Acs Chem.Biol., 8:1215-1222, 2013; PubMed: 23527544; DOI: 10.1021/cb400012k

実験手法

X-RAY DIFFRACTION (1.8 Å)