4HGE
JAK2 kinase (JH1 domain) in complex with compound 8
Summary for 4HGE
Entry DOI | 10.2210/pdb4hge/pdb |
Descriptor | Tyrosine-protein kinase JAK2, N-[1-(3-chlorophenyl)-3-methyl-1H-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total) |
Functional Keywords | protein kinase, phosphotransfer, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system; Peripheral membrane protein (By similarity): O60674 |
Total number of polymer chains | 2 |
Total formula weight | 71389.81 |
Authors | Eigenbrot, C.,Ultsch, M. (deposition date: 2012-10-08, release date: 2012-10-24, Last modification date: 2023-12-06) |
Primary citation | Hanan, E.J.,van Abbema, A.,Barrett, K.,Blair, W.S.,Blaney, J.,Chang, C.,Eigenbrot, C.,Flynn, S.,Gibbons, P.,Hurley, C.A.,Kenny, J.R.,Kulagowski, J.,Lee, L.,Magnuson, S.R.,Morris, C.,Murray, J.,Pastor, R.M.,Rawson, T.,Siu, M.,Ultsch, M.,Zhou, A.,Sampath, D.,Lyssikatos, J.P. Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors. J.Med.Chem., 55:10090-10107, 2012 Cited by PubMed: 23061660DOI: 10.1021/jm3012239 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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