4HGE

JAK2 kinase (JH1 domain) in complex with compound 8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase JAK2	polymer	300	35342.1	2	UniProt (O60674) Pfam (PF07714)	Homo sapiens (human)	Janus kinase 2, JAK-2
2	C, D (A, B)	N-[1-(3-chlorophenyl)-3-methyl-1H-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide	non-polymer		352.8	2	Chemie (15V)
3	E, F (A, B)	water	water		18.0	182	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70684.3
Non-Polymers*	Number of molecules	2
	Total formula weight	705.6
All*	Total formula weight	71389.8

*Water molecules are not included.