4HGC

Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1

Summary for 4HGC

• Entry DOI: 10.2210/pdb4hgc/pdb
• Related: 1SFI 3MI4 3P8F
• Related PRD ID: PRD_001025
• Descriptor: Cationic trypsin, Trypsin inhibitor 1, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: hydrolase, serine protease, cyclic peptide, peptoid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Bos taurus (cow); More
• Cellular location: Secreted, extracellular space: P00760
• Total number of polymer chains: 2
• Total formula weight: 25647.85

Authors

Krzywda, S.,Jaskolski, M.,Rolka, K.,Stawikowski, M. (deposition date: 2012-10-08, release date: 2013-10-09, Last modification date: 2023-11-15)

• Primary citation: Krzywda, S.,Jaskolski, M.,Rolka, K.,Stawikowski, M.J.; Structure of a proteolytically resistant analogue of (NLys)(5)SFTI-1 in complex with trypsin: evidence for the direct participation of the Ser214 carbonyl group in serine protease-mediated proteolysis.; Acta Crystallogr.,Sect.D, 70:668-675, 2014; PubMed: 24598736; DOI: 10.1107/S1399004713032252

Experimental method

X-RAY DIFFRACTION (1.29 Å)