4HGC

Crystal structure of bovine trypsin complexed with sfti-1 analog containing a peptoid residue at position p1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0007586	biological_process	digestion
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0097180	cellular_component	serine protease inhibitor complex
A	0097655	molecular_function	serpin family protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 301

Chain	Residue
A	GLU70
A	ASN72
A	VAL75
A	GLU80
A	HOH408
A	HOH419

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 302

Chain	Residue
A	PHE181
A	LYS230
A	GOL305
A	HOH450
A	ALA129
A	LEU163
A	ASP165

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 303

Chain	Residue
A	TYR20
A	CYS22
A	THR26
A	HOH632

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 304

Chain	Residue
A	TYR39
A	HIS40
A	ILE73
A	ASN74
A	SER166
A	GOL305
A	HOH539
A	HOH583
A	HOH633
A	HOH671
A	HOH673

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 305

Chain	Residue
A	ALA132
A	SER164
A	ASP165
A	SER166
A	GOL302
A	GOL304
A	HOH583

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 306

Chain	Residue
A	GLN135
A	CYS136
A	LEU137
A	VAL200
A	CYS201
A	SER202
A	GLY203
A	HOH551

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 307

Chain	Residue
A	LYS169
A	GLY174
A	HOH466
A	HOH505
A	HOH657

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 308

Chain	Residue
A	PRO152
A	ASP153
A	VAL154
A	LYS156
A	HOH587
A	HOH649

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 309

Chain	Residue
A	ARG66
A	SER166
A	SER167
A	SER170
A	HOH477
A	HOH539
A	HOH549
A	HOH559
A	HOH581
A	HOH633

---

site_id	BC1
Number of Residues	28
Details	BINDING SITE FOR CHAIN I OF TRYPSIN INHIBITOR 1

Chain	Residue
A	HIS40
A	PHE41
A	HIS57
A	SER96
A	ASN97
A	LEU99
A	GLN175
A	ASP189
A	SER190
A	CYS191
A	GLN192
A	GLY193
A	ASP194
A	SER195
A	SER214
A	TRP215
A	GLY216
A	SER217
A	GLY219
A	HOH415
A	HOH424
A	HOH458
A	HOH465
I	HOH102
I	HOH103
I	HOH106
I	HOH107
I	HOH108

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
A	VAL53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV

Chain	Residue	Details
A	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {}

Chain

Residue

Details

---