4HEE

Crystal structure of PPARgamma in complex with compound 13

4HEE の概要

• エントリーDOI: 10.2210/pdb4hee/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 5-benzyl-2-ethyl-3-{(1S)-5-[2-(1H-tetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl}-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one, ... (4 entities in total)
• 機能のキーワード: ppargamma, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P37231; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35649.30

構造登録者

Han, S. (登録日: 2012-10-03, 公開日: 2013-08-21, 最終更新日: 2024-02-28)

• 主引用文献: Casimiro-Garcia, A.,Heemstra, R.J.,Bigge, C.F.,Chen, J.,Ciske, F.A.,Davis, J.A.,Ellis, T.,Esmaeil, N.,Flynn, D.,Han, S.,Jalaie, M.,Ohren, J.F.,Powell, N.A.; Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-gamma; Bioorg.Med.Chem.Lett., 23:767-772, 2013; PubMed: 23265881; DOI: 10.1016/j.bmcl.2012.11.088

実験手法

X-RAY DIFFRACTION (2.5 Å)