4HBV

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand

4HBV の概要

• エントリーDOI: 10.2210/pdb4hbv/pdb
• 関連するPDBエントリー: 4HBV 4HBW 4HBY
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 6-bromo-3-methyl-3,4-dihydroquinazolin-2(1H)-one, ... (4 entities in total)
• 機能のキーワード: bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, structural genomics consortium, sgc, protein binding/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (By similarity): O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15464.60

構造登録者

Filippakopoulos, P.,Picaud, S.,Qi, J.,Felletar, I.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Fish, P.V.,Bunnage, M.E.,Cook, A.S.,Owen, D.R.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2012-09-28, 公開日: 2012-10-31, 最終更新日: 2023-09-20)

• 主引用文献: Fish, P.V.,Filippakopoulos, P.,Bish, G.,Brennan, P.E.,Bunnage, M.E.,Cook, A.S.,Federov, O.,Gerstenberger, B.S.,Jones, H.,Knapp, S.,Marsden, B.,Nocka, K.,Owen, D.R.,Philpott, M.,Picaud, S.,Primiano, M.J.,Ralph, M.J.,Sciammetta, N.,Trzupek, J.D.; Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit.; J.Med.Chem., 55:9831-9837, 2012; PubMed: 23095041; DOI: 10.1021/jm3010515

実験手法

X-RAY DIFFRACTION (1.63 Å)