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4HBV

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand

Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 201
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 202
ChainResidue
AHOH402
ALEU92
ALYS99
A15E203
AHOH333

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE 15E A 203
ChainResidue
ATRP81
APRO82
APHE83
AASN140
AILE146
AEDO202
AHOH309
AHOH379

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

222415

PDB entries from 2024-07-10

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