4HBN
Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation
Summary for 4HBN
Entry DOI | 10.2210/pdb4hbn/pdb |
Descriptor | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | camp binding, camp, neuropeptide |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Multi-pass membrane protein: Q9Y3Q4 |
Total number of polymer chains | 1 |
Total formula weight | 24635.92 |
Authors | Xu, X.,Marni, F.,Wu, X.,Su, Z.,Musayev, F.,Shrestha, S.,Xie, C.,Gao, W.,Liu, Q.,Zhou, L. (deposition date: 2012-09-28, release date: 2013-01-16, Last modification date: 2024-02-28) |
Primary citation | Xu, X.,Marni, F.,Wu, S.,Su, Z.,Musayev, F.,Shrestha, S.,Xie, C.,Gao, W.,Liu, Q.,Zhou, L. Local and Global Interpretations of a Disease-Causing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel. Structure, 20:2116-2123, 2012 Cited by PubMed: 23103389DOI: 10.1016/j.str.2012.09.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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