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4HBN

Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation

Summary for 4HBN
Entry DOI10.2210/pdb4hbn/pdb
DescriptorPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PHOSPHATE ION, ... (4 entities in total)
Functional Keywordscamp binding, camp, neuropeptide
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Multi-pass membrane protein: Q9Y3Q4
Total number of polymer chains1
Total formula weight24635.92
Authors
Xu, X.,Marni, F.,Wu, X.,Su, Z.,Musayev, F.,Shrestha, S.,Xie, C.,Gao, W.,Liu, Q.,Zhou, L. (deposition date: 2012-09-28, release date: 2013-01-16, Last modification date: 2024-02-28)
Primary citationXu, X.,Marni, F.,Wu, S.,Su, Z.,Musayev, F.,Shrestha, S.,Xie, C.,Gao, W.,Liu, Q.,Zhou, L.
Local and Global Interpretations of a Disease-Causing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel.
Structure, 20:2116-2123, 2012
Cited by
PubMed: 23103389
DOI: 10.1016/j.str.2012.09.017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

数据于2024-03-27公开中

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