4HBN

Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation

4HBN の概要

• エントリーDOI: 10.2210/pdb4hbn/pdb
• 分子名称: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: camp binding, camp, neuropeptide
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Multi-pass membrane protein: Q9Y3Q4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24635.92

構造登録者

Xu, X.,Marni, F.,Wu, X.,Su, Z.,Musayev, F.,Shrestha, S.,Xie, C.,Gao, W.,Liu, Q.,Zhou, L. (登録日: 2012-09-28, 公開日: 2013-01-16, 最終更新日: 2024-02-28)

• 主引用文献: Xu, X.,Marni, F.,Wu, S.,Su, Z.,Musayev, F.,Shrestha, S.,Xie, C.,Gao, W.,Liu, Q.,Zhou, L.; Local and Global Interpretations of a Disease-Causing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel.; Structure, 20:2116-2123, 2012; PubMed: 23103389; DOI: 10.1016/j.str.2012.09.017

実験手法

X-RAY DIFFRACTION (2.6 Å)