4GYE
MDR 769 HIV-1 Protease in Complex with Reduced P1F
Summary for 4GYE
Entry DOI | 10.2210/pdb4gye/pdb |
Related | 4GZF |
Related PRD ID | PRD_000778 |
Descriptor | Protease, P1F peptide (3 entities in total) |
Functional Keywords | multi-drug resistance, protease inhibitor, drug resistance, substrate peptide, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 3 |
Total formula weight | 22409.42 |
Authors | Dewdney, T.G.,Wang, Y.,Brunzelle, J.,Reiter, S.J.,Kovari, I.A.,Kovari, L.C. (deposition date: 2012-09-05, release date: 2013-10-30, Last modification date: 2023-11-15) |
Primary citation | Dewdney, T.G.,Wang, Y.,Liu, Z.,Sharma, S.K.,Reiter, S.J.,Brunzelle, J.S.,Kovari, I.A.,Woster, P.M.,Kovari, L.C. Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease. Bioorg.Med.Chem., 21:7430-7434, 2013 Cited by PubMed: 24128815DOI: 10.1016/j.bmc.2013.09.045 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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