4GV4
Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0328
Summary for 4GV4
Entry DOI | 10.2210/pdb4gv4/pdb |
Related | 4GV0 4GV2 |
Descriptor | Poly [ADP-ribose] polymerase 3, 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-phenylethyl]propanamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | nad, adp-ribose, parp3, artd3, artd transferase domain, adp- ribosylation, transferase-transferase inhibitor complex, transferase, adp-ribosylation, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q9Y6F1 |
Total number of polymer chains | 1 |
Total formula weight | 40151.58 |
Authors | Karlberg, T.,Thorsell, A.G.,Lindgren, A.E.G.,Ekblad, T.,Spjut, S.,Andersson, C.D.,Weigelt, J.,Linusson, A.,Elofsson, M.,Schuler, H. (deposition date: 2012-08-30, release date: 2013-06-19, Last modification date: 2023-11-08) |
Primary citation | Lindgren, A.E.G.,Karlberg, T.,Thorsell, A.G.,Hesse, M.,Spjut, S.,Ekblad, T.,Andersson, C.D.,Pinto, A.F.,Weigelt, J.,Hottiger, M.O.,Linusson, A.,Elofsson, M.,Schuler, H. PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3 Acs Chem.Biol., 8:1698-1703, 2013 Cited by PubMed: 23742272DOI: 10.1021/cb4002014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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