4GV3

Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production

Summary for 4GV3

• Entry DOI: 10.2210/pdb4gv3/pdb
• Related: 3MWP 4G9Z
• Descriptor: RNA (5'-R(*(GTP)P*GP*GP*C)-3'), RNA (5'-R(P*CP*GP*CP*CP*C)-3'), Nucleoprotein, ... (6 entities in total)
• Functional Keywords: ddedh family, 3'-5'exoribonuclease, rna binding protein-rna complex, rna binding protein/rna
• Biological source: Lassa virus (LASV)
• Cellular location: Virion: P13699
• Total number of polymer chains: 3
• Total formula weight: 27167.80

Authors

Jiang, X.,Huang, Q.,Wang, W.,Dong, H.,Ly, H.,Liang, Y.,Dong, C. (deposition date: 2012-08-30, release date: 2013-05-01, Last modification date: 2024-02-28)

• Primary citation: Jiang, X.,Huang, Q.,Wang, W.,Dong, H.,Ly, H.,Liang, Y.,Dong, C.; Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.; J.Biol.Chem., 288:16949-16959, 2013; PubMed: 23615902; DOI: 10.1074/jbc.M112.420521

Experimental method

X-RAY DIFFRACTION (1.68 Å)