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4GV3

Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1BRNA (5'-R(*(GTP)P*GP*GP*C)-3')polymer41455.81
2CRNA (5'-R(P*CP*GP*CP*CP*C)-3')polymer51521.01
3ANucleoproteinpolymer21424070.71UniProt (P13699)
Pfam (PF17290)
In PDB
Lassa virus (LASV)Nucleocapsid protein, Protein N
4BMANGANESE (II) IONnon-polymer54.91Chemie (MN)
5AZINC IONnon-polymer65.41Chemie (ZN)
6waterwater18.0177Chemie (HOH)
Sequence modifications
A: 364 - 569 (UniProt: P13699)
PDBExternal DatabaseDetails
Gly 356-expression tag
Ala 357-expression tag
Met 358-expression tag
Asp 359-expression tag
His 360-expression tag
Val 361-expression tag
Glu 362-expression tag
Phe 363-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight27047.5
Non-Polymers*Number of molecules2
Total formula weight120.3
All*Total formula weight27167.8
*Water molecules are not included.

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PDB entries from 2024-03-27

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