4GV3
Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | RNA (5'-R(*(GTP)P*GP*GP*C)-3') | polymer | 4 | 1455.8 | 1 | |||
| 2 | B (C) | RNA (5'-R(P*CP*GP*CP*CP*C)-3') | polymer | 5 | 1521.0 | 1 | |||
| 3 | C (A) | Nucleoprotein | polymer | 214 | 24070.7 | 1 | UniProt (P13699) Pfam (PF17290) | Lassa virus (LASV) | Nucleocapsid protein, Protein N |
| 4 | D (B) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 5 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | F, G, H (B, C, A) | water | water | 18.0 | 177 | Chemie (HOH) |
Sequence modifications
A: 364 - 569 (UniProt: P13699)
| PDB | External Database | Details |
|---|---|---|
| Gly 356 | - | expression tag |
| Ala 357 | - | expression tag |
| Met 358 | - | expression tag |
| Asp 359 | - | expression tag |
| His 360 | - | expression tag |
| Val 361 | - | expression tag |
| Glu 362 | - | expression tag |
| Phe 363 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 27047.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 120.3 | |
| All* | Total formula weight | 27167.8 |
