4GV3
Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 101 |
| Chain | Residue |
| A | ASP389 |
| A | HOH703 |
| A | HOH718 |
| A | HOH804 |
| B | G10 |
| B | C11 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 601 |
| Chain | Residue |
| A | CYS529 |
| A | GLU399 |
| A | CYS506 |
| A | HIS509 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04085","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21085117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21262835","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04085","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21085117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21262835","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22937163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23615902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for exonuclease activity","evidences":[{"source":"HAMAP-Rule","id":"MF_04085","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21085117","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
