4GU9

Focal adhesion kinase catalytic domain in complex with (2-Fluoro-phenyl)-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)-amine

Summary for 4GU9

Entry DOI	10.2210/pdb4gu9/pdb
Descriptor	Focal adhesion kinase 1, N-(2-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
Functional Keywords	protein tyrosine kinase, transferase, atp binding
Biological source	Homo sapiens (human)
Cellular location	Cell junction, focal adhesion: Q05397
Total number of polymer chains	2
Total formula weight	64374.28
Authors	Musil, D. (deposition date: 2012-08-29, release date: 2013-09-04, Last modification date: 2023-09-13)
Primary citation	Heinrich, T.,Seenisamy, J.,Emmanuvel, L.,Kulkarni, S.S.,Bomke, J.,Rohdich, F.,Greiner, H.,Esdar, C.,Krier, M.,Gradler, U.,Musil, D. Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors. J.Med.Chem., 56:1160-1170, 2013 Cited by PubMed: 23294348 DOI: 10.1021/jm3016014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation