4GTO

FTase in complex with BMS analogue 14

Summary for 4GTO

• Entry DOI: 10.2210/pdb4gto/pdb
• Related: 4GTM 4GTP 4GTQ 4GTR 4GTS 4GTT 4GTV
• Descriptor: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, ZINC ION, ... (7 entities in total)
• Functional Keywords: protein prenylation, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Rattus norvegicus (rat); More
• Total number of polymer chains: 2
• Total formula weight: 93049.05

Authors

Guo, Z.,Stigter, E.A.,Bon, R.S.,Waldmann, H.,Blankenfeldt, W.,Goody, R.S. (deposition date: 2012-08-29, release date: 2012-10-24, Last modification date: 2023-11-08)

• Primary citation: Stigter, E.A.,Guo, Z.,Bon, R.S.,Wu, Y.W.,Choidas, A.,Wolf, A.,Menninger, S.,Waldmann, H.,Blankenfeldt, W.,Goody, R.S.; Development of Selective, Potent RabGGTase Inhibitors; J.Med.Chem., 55:8330-8340, 2012; PubMed: 22963166; DOI: 10.1021/jm300624s

Experimental method

X-RAY DIFFRACTION (2.15 Å)