4GS6
Irreversible Inhibition of TAK1 Kinase by 5Z-7-Oxozeaenol
Summary for 4GS6
Entry DOI | 10.2210/pdb4gs6/pdb |
Related | 2EVA |
Descriptor | Tak1-Tab1 fusion protein, 1,2-ETHANEDIOL, (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione, ... (4 entities in total) |
Functional Keywords | kinase fold, tab1 binding, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 36503.97 |
Authors | Larsen, N.A.,Ferguson, A.D.,Wu, J. (deposition date: 2012-08-27, release date: 2013-01-23, Last modification date: 2017-08-02) |
Primary citation | Wu, J.,Powell, F.,Larsen, N.A.,Lai, Z.,Byth, K.F.,Read, J.,Gu, R.F.,Roth, M.,Toader, D.,Saeh, J.C.,Chen, H. Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)-7-Oxozeaenol. Acs Chem.Biol., 8:643-650, 2013 Cited by PubMed: 23272696DOI: 10.1021/cb3005897 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report