4GS6
Irreversible Inhibition of TAK1 Kinase by 5Z-7-Oxozeaenol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tak1-Tab1 fusion protein | polymer | 315 | 35520.9 | 1 | UniProt (O43318) UniProt (Q15750) Pfam (PF07714) In PDB | Homo sapiens (human) | Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1 |
| 2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 3 | A | (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione | non-polymer | 362.4 | 1 | Chemie (1FM) | |||
| 4 | water | water | 18.0 | 159 | Chemie (HOH) |
Sequence modifications
A: 31 - 303 (UniProt: O43318)
A: 468 - 504 (UniProt: Q15750)
| PDB | External Database | Details |
|---|---|---|
| Gly 26 | - | EXPRESSION TAG |
| Ser 27 | - | EXPRESSION TAG |
| Leu 28 | - | EXPRESSION TAG |
| His 29 | - | EXPRESSION TAG |
| Met 30 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35520.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 983.1 | |
| All* | Total formula weight | 36504.0 |
