4GLS

Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21

4GLS の概要

• エントリーDOI: 10.2210/pdb4gls/pdb
• 関連するPDBエントリー: 3QTK 4GLN 4GLU
• 分子名称: D- Vascular endothelial growth factor-A, L- RFX001, D- RFX001, ... (7 entities in total)
• 機能のキーワード: heterochiral protein-protein complex, d-protein antagonist, growth factor-inhibitor complex, growth factor/inhibitor
• 細胞内の位置: Secreted: P15692
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 73492.41

構造登録者

Mandal, K.,Uppalapati, M.,Ault-Riche, D.,Kenney, J.,Lowitz, J.,Sidhu, S.,Kent, S.B.H. (登録日: 2012-08-14, 公開日: 2012-09-05, 最終更新日: 2023-12-06)

• 主引用文献: Mandal, K.,Uppalapati, M.,Ault-Riche, D.,Kenney, J.,Lowitz, J.,Sidhu, S.S.,Kent, S.B.; Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.; Proc.Natl.Acad.Sci.USA, 109:14779-14784, 2012; PubMed: 22927390; DOI: 10.1073/pnas.1210483109

実験手法

X-RAY DIFFRACTION (1.6 Å)