4GLR

Structure of the anti-ptau Fab (pT231/pS235_1) in complex with phosphoepitope pT231/pS235

Summary for 4GLR

• Entry DOI: 10.2210/pdb4glr/pdb
• Related: 3BN9 3G6D 3GJE 3H42 3KYM 3MA9
• Descriptor: phospho-peptide, anti-ptau heavy chain, anti-ptau light chain, ... (5 entities in total)
• Functional Keywords: igg1 fab, anti-ptau antibody, phosphorylated tau peptide, phosphorylation, immune system
• Biological source: Gallus gallus (chicken); More
• Total number of polymer chains: 6
• Total formula weight: 95855.81

Authors

Tu, C.,Mosyak, L.,Bard, J. (deposition date: 2012-08-14, release date: 2012-11-21, Last modification date: 2023-09-13)

• Primary citation: Shih, H.H.,Tu, C.,Cao, W.,Klein, A.,Ramsey, R.,Fennell, B.J.,Lambert, M.,Ni Shuilleabhain, D.,Autin, B.,Kouranova, E.,Laxmanan, S.,Braithwaite, S.,Wu, L.,Ait-Zahra, M.,Milici, A.J.,Dumin, J.A.,Lavallie, E.R.,Arai, M.,Corcoran, C.,Paulsen, J.E.,Gill, D.,Cunningham, O.,Bard, J.,Mosyak, L.,Finlay, W.J.; An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition.; J.Biol.Chem., 287:44425-44434, 2012; PubMed: 23148212; DOI: 10.1074/jbc.M112.415935

Experimental method

X-RAY DIFFRACTION (1.9 Å)