4GH8
Crystal structure of a 'humanized' E. coli dihydrofolate reductase
Summary for 4GH8
| Entry DOI | 10.2210/pdb4gh8/pdb |
| Descriptor | Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
| Functional Keywords | tetrahydrofolate, enzyme catalysis, evolution, dihydrofolate reductase, oxidoreductase |
| Biological source | Escherichia coli |
| Total number of polymer chains | 2 |
| Total formula weight | 39229.42 |
| Authors | French, J.B.,Liu, C.T.,Hanoian, P.,Pringle, T.H.,Hammes-Schiffer, S.,Benkovic, S.J. (deposition date: 2012-08-07, release date: 2013-06-05, Last modification date: 2024-02-28) |
| Primary citation | Liu, C.T.,Hanoian, P.,French, J.B.,Pringle, T.H.,Hammes-Schiffer, S.,Benkovic, S.J. Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans. Proc.Natl.Acad.Sci.USA, 110:10159-10164, 2013 Cited by PubMed: 23733948DOI: 10.1073/pnas.1307130110 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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