Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0006545 | biological_process | glycine biosynthetic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0006545 | biological_process | glycine biosynthetic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE MTX B 201 |
| Chain | Residue |
| B | ILE5 |
| B | ASN55 |
| B | ARG61 |
| B | ILE98 |
| B | TYR104 |
| B | THR117 |
| B | NDP202 |
| B | HOH303 |
| B | HOH318 |
| B | HOH330 |
| B | HOH366 |
| B | ALA6 |
| B | ALA7 |
| B | MET20 |
| B | ASP28 |
| B | LEU29 |
| B | PHE32 |
| B | LYS33 |
| B | SER50 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NDP B 202 |
| Chain | Residue |
| B | ALA6 |
| B | ALA7 |
| B | ILE14 |
| B | GLY15 |
| B | ASN18 |
| B | ALA19 |
| B | GLY44 |
| B | ARG45 |
| B | HIS46 |
| B | THR47 |
| B | LEU66 |
| B | SER67 |
| B | SER68 |
| B | LYS80 |
| B | ILE98 |
| B | GLY100 |
| B | GLY101 |
| B | ARG102 |
| B | VAL103 |
| B | TYR104 |
| B | GLN106 |
| B | MTX201 |
| B | HOH302 |
| B | HOH312 |
| B | HOH335 |
| B | HOH339 |
| B | HOH340 |
| B | HOH353 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B 203 |
| Chain | Residue |
| B | GLU53 |
| B | ARG56 |
| B | HOH365 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE MTX A 201 |
| Chain | Residue |
| A | ILE5 |
| A | ALA6 |
| A | MET20 |
| A | ASP28 |
| A | PHE32 |
| A | LYS33 |
| A | ASN55 |
| A | ARG61 |
| A | ILE98 |
| A | TYR104 |
| A | THR117 |
| A | NDP202 |
| A | HOH305 |
| A | HOH360 |
| A | HOH395 |
| site_id | AC5 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NDP A 202 |
| Chain | Residue |
| A | ALA6 |
| A | ALA7 |
| A | ILE14 |
| A | GLY15 |
| A | ASN18 |
| A | ALA19 |
| A | GLY44 |
| A | ARG45 |
| A | HIS46 |
| A | THR47 |
| A | LEU66 |
| A | SER67 |
| A | SER68 |
| A | LYS80 |
| A | ILE98 |
| A | GLY100 |
| A | GLY101 |
| A | ARG102 |
| A | VAL103 |
| A | TYR104 |
| A | GLN106 |
| A | MTX201 |
| A | HOH303 |
| A | HOH321 |
| A | HOH330 |
| A | HOH343 |
| A | HOH357 |
| A | HOH364 |
| A | HOH384 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 203 |
| Chain | Residue |
| A | ASP131 |
| A | GLU133 |
| A | HOH354 |
| A | HOH355 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 204 |
| Chain | Residue |
| A | ARG56 |
| A | HOH370 |
| A | GLU53 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 24 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWpplpaDlawFkrnT |
| Chain | Residue | Details |
| B | VAL13-THR36 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | ILE5 | |
| A | THR117 | |
| B | ASP28 | |
| B | ARG56 | |
| B | ARG61 | |
| B | THR117 | |
| A | ILE5 | |
| A | ASP28 | |
| A | ARG56 | |
| A | ARG61 | |
| Chain | Residue | Details |
| B | ALA7 | |
| A | SER67 | |
| A | LYS80 | |
| A | GLY99 | |
| B | VAL13 | |
| B | HIS46 | |
| B | SER67 | |
| B | LYS80 | |
| B | GLY99 | |
| A | ALA7 | |
| A | VAL13 | |
| A | HIS46 | |
