4GH8
Crystal structure of a 'humanized' E. coli dihydrofolate reductase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Dihydrofolate reductase | polymer | 162 | 18354.7 | 2 | UniProt (P0ABQ4) Pfam (PF00186) In PDB | Escherichia coli | |
2 | B, A | METHOTREXATE | non-polymer | 454.4 | 2 | Chemie (MTX) | |||
3 | B, A | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
4 | B, A | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
5 | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 162 (UniProt: P0ABQ4)
PDB | External Database | Details |
---|---|---|
Pro 23 | Asn 23 | SEE REMARK 999 |
Pro 24 | Asn 23 | SEE REMARK 999 |
Pro 52 | Gly 51 | SEE REMARK 999 |
Glu 53 | Gly 51 | SEE REMARK 999 |
Lys 54 | Gly 51 | SEE REMARK 999 |
Asn 55 | Gly 51 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 36709.5 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 2520.0 | |
All* | Total formula weight | 39229.4 |