4GH1

tRNA Guanine Transglycosylase in complex with morpholine substituted lin-benzohypoxanthine inhibitor

Summary for 4GH1

• Entry DOI: 10.2210/pdb4gh1/pdb
• Related: 3S1G 3SM0 3TLL 4GG9 4GH3 4GHR 4GI4
• Descriptor: Queuine tRNA-ribosyltransferase, ZINC ION, 4-{2-[(cyclohexylmethyl)amino]ethyl}-2-{[2-(morpholin-4-yl)ethyl]amino}-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ... (5 entities in total)
• Functional Keywords: tim barrel, glycosyltransferase, queuosine, biosynthesis, trna processing, trna, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Zymomonas mobilis subsp. mobilis
• Total number of polymer chains: 1
• Total formula weight: 43536.79

Authors

Immekus, F.,Klebe, G. (deposition date: 2012-08-07, release date: 2013-09-04, Last modification date: 2023-09-13)

• Primary citation: Immekus, F.,Barandun, L.J.,Diederich, F.,Klebe, G.; Two-armed benzopurine inhibitors of TGT; To be Published,

Experimental method

X-RAY DIFFRACTION (1.45 Å)