4GGL
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity
4GGL の概要
エントリーDOI | 10.2210/pdb4ggl/pdb |
関連するPDBエントリー | 4GEE 4GFN 4HXW 4HXZ 4HY1 4HYM 4HYP 4HZ0 4HZ5 |
分子名称 | DNA gyrase subunit B, 7-({4-[(3R)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)pyrido[2,3-b]pyrazin-2(1H)-one, GLYCEROL, ... (4 entities in total) |
機能のキーワード | atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, dna gyrase negatively supercoils closed circular double-stranded dna in an atp-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded dna rings, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
由来する生物種 | Enterococcus faecalis |
細胞内の位置 | Cytoplasm (By similarity): Q839Z1 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 24370.63 |
構造登録者 | |
主引用文献 | Tari, L.W.,Trzoss, M.,Bensen, D.C.,Li, X.,Chen, Z.,Lam, T.,Zhang, J.,Creighton, C.J.,Cunningham, M.L.,Kwan, B.,Stidham, M.,Shaw, K.J.,Lightstone, F.C.,Wong, S.E.,Nguyen, T.B.,Nix, J.,Finn, J. Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23:1529-1536, 2013 Cited by PubMed: 23352267DOI: 10.1016/j.bmcl.2012.11.032 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.69 Å) |
構造検証レポート
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