4GGL

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE CJC A 301

Chain	Residue
A	ASN48
A	SER122
A	THR167
A	VAL169
A	HOH412
A	HOH423
A	HOH494
A	HOH561
A	HOH614
A	SER49
A	GLU52
A	ASP75
A	ARG78
A	GLY79
A	ILE80
A	PRO81
A	GLY119

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 302

Chain	Residue
A	ALA53
A	THR130
A	ARG148
A	ARG149
A	ASN200
A	ARG201
A	LEU203
A	HOH498
A	HOH616

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