4GFM

JAK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE

Summary for 4GFM

• Entry DOI: 10.2210/pdb4gfm/pdb
• Related: 4GFO 4GIH 4GMY
• Descriptor: Tyrosine-protein kinase JAK2, 2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide (3 entities in total)
• Functional Keywords: o-phosphotyrosine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Endomembrane system; Peripheral membrane protein (By similarity): O60674
• Total number of polymer chains: 1
• Total formula weight: 35769.36

Authors

Eigenbrot, C.,Ultsch, M. (deposition date: 2012-08-03, release date: 2013-06-19, Last modification date: 2023-12-06)

• Primary citation: Liang, J.,Tsui, V.,Van Abbema, A.,Bao, L.,Barrett, K.,Beresini, M.,Berezhkovskiy, L.,Blair, W.S.,Chang, C.,Driscoll, J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Halladay, J.,Johnson, A.,Kohli, P.B.,Lai, Y.,Liimatta, M.,Mantik, P.,Menghrajani, K.,Murray, J.,Sambrone, A.,Xiao, Y.,Shia, S.,Shin, Y.,Smith, J.,Sohn, S.,Stanley, M.,Ultsch, M.,Zhang, B.,Wu, L.C.,Magnuson, S.; Lead identification of novel and selective TYK2 inhibitors.; Eur.J.Med.Chem., 67:175-187, 2013; PubMed: 23867602; DOI: 10.1016/j.ejmech.2013.03.070

Experimental method

X-RAY DIFFRACTION (2.3 Å)