4GFG

Crystal structure of spleen tyrosine kinase complexed with r9021

Summary for 4GFG

• Entry DOI: 10.2210/pdb4gfg/pdb
• Related: 3FQE
• Descriptor: Tyrosine-protein kinase SYK, 6-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(5,6-dimethylpyridin-2-yl)amino]pyridazine-3-carboxamide (3 entities in total)
• Functional Keywords: syk, spleen typrosine kinase, pyrimidine-5-carboxamide, atp-binding, host-virus interaction, nucleotide-binding, phosphoprotein, sh2 domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane : P43405
• Total number of polymer chains: 1
• Total formula weight: 34239.44

Authors

Lukacs, C.,Slade, M. (deposition date: 2012-08-03, release date: 2013-08-14, Last modification date: 2023-09-13)

• Primary citation: Hsu, J.,Kim, Y.,Hu, D.-Q.,Xu, D.,Zhang, J.,Pashine, A.,Menke, J.,Whittard, T.,Romero, N.,Truitt, T.,Lukacs, C.,Zhou, M.,Lucas, M.,Slade, M.,DeMartino, J.,Tan, S.-L.,Liao, C.; A specific SYK inhibitor blocks B Cell Receptor, Fc Receptor, and Toll-like Receptor 9 pathways for the treatment of inflammatory diseases.; To be Published,

Experimental method

X-RAY DIFFRACTION (2.35 Å)