3FQE

Crystal structure of spleen tyrosine kinase complexed with YM193306

Summary for 3FQE

Entry DOI	10.2210/pdb3fqe/pdb
Related	3FQH 3FQS
Descriptor	Tyrosine-protein kinase SYK, 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide (3 entities in total)
Functional Keywords	syk, spleen typrosine kinase, kinase inhibitor, pyrimidine-5-carboxamide, atp-binding, host-virus interaction, kinase, nucleotide-binding, phosphoprotein, sh2 domain, transferase, tyrosine-protein kinase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34224.43
Authors	Kuglstatter, A.,Villasenor, A.G. (deposition date: 2009-01-07, release date: 2009-03-10, Last modification date: 2023-09-06)
Primary citation	Villasenor, A.G.,Kondru, R.,Ho, H.,Wang, S.,Papp, E.,Shaw, D.,Barnett, J.W.,Browner, M.F.,Kuglstatter, A. Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes. Chem.Biol.Drug Des., 73:466-470, 2009 Cited by PubMed: 19220318 DOI: 10.1111/j.1747-0285.2009.00785.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation