4GCF

Room temperature X-ray diffraction study of a 6-fold molar excess of a cisplatin/carboplatin mixture binding to HEWL, Dataset 4

4GCF の概要

• エントリーDOI: 10.2210/pdb4gcf/pdb
• 関連するPDBエントリー: 4DD0 4DD1 4DD2 4DD3 4DD4 4DD6 4DD7 4DD9 4DDA 4DDB 4DDC 4G49 4G4A 4G4B 4G4C 4G4H 4GCB 4GCC 4GCD 4GCE 4GCJ
• 分子名称: Lysozyme C, PLATINUM (II) ION, DIMETHYL SULFOXIDE (3 entities in total)
• 機能のキーワード: cisplatin, carboplatin, histidine, relative toxicity, binding occupancy, x-ray radiation damage, radiation therapy, temperature variation and structure, hydrolase
• 由来する生物種: Gallus gallus (chicken)
• 細胞内の位置: Secreted: P00698
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14799.45

構造登録者

Helliwell, J.R.,Tanley, S.W.M. (登録日: 2012-07-30, 公開日: 2013-01-02, 最終更新日: 2023-09-13)

• 主引用文献: Helliwell, J.R.,Tanley, S.W.; The crystal structure analysis of the relative binding of cisplatin and carboplatin in a mixture with histidine in a protein studied at 100 and 300 K with repeated X-ray irradiation.; Acta Crystallogr.,Sect.D, 69:121-125, 2013; PubMed: 23275170; DOI: 10.1107/S090744491204423X

実験手法

X-RAY DIFFRACTION (3.5 Å)