4G8R

Crystal Structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1

Summary for 4G8R

• Entry DOI: 10.2210/pdb4g8r/pdb
• Related: 1B3K 4G8O
• Descriptor: Plasminogen activator inhibitor-1, SULFATE ION, (2S)-3-({[3-(trifluoromethyl)phenoxy]carbonyl}amino)propane-1,2-diyl bis(3,4,5-trihydroxybenzoate), ... (4 entities in total)
• Functional Keywords: serpin, pai-1, inhibitor, blood clotting, blood clotting-inhibitor complex, blood clotting/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P05121
• Total number of polymer chains: 2
• Total formula weight: 86024.04

Authors

Stuckey, J.A.,Lawrence, D.A.,Li, S.-H. (deposition date: 2012-07-23, release date: 2013-12-25, Last modification date: 2024-02-28)

• Primary citation: Li, S.H.,Reinke, A.A.,Sanders, K.L.,Emal, C.D.,Whisstock, J.C.,Stuckey, J.A.,Lawrence, D.A.; Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1.; Proc.Natl.Acad.Sci.USA, 110:E4941-E4949, 2013; PubMed: 24297881; DOI: 10.1073/pnas.1216499110

Experimental method

X-RAY DIFFRACTION (2.19 Å)