4G5S
Structure of LGN GL3/Galphai3 complex
Summary for 4G5S
Entry DOI | 10.2210/pdb4g5s/pdb |
Related | 4G5O 4G5Q 4G5R |
Descriptor | Guanine nucleotide-binding protein G(k) subunit alpha, G-protein-signaling modulator 2, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | galpha, goloco, galpha signaling, asymmetric cell division, cell cycle-signaling protein complex, cell cycle/signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P08754 Cytoplasm (By similarity): Q8VDU0 |
Total number of polymer chains | 8 |
Total formula weight | 164758.52 |
Authors | |
Primary citation | Jia, M.,Li, J.,Zhu, J.,Wen, W.,Zhang, M.,Wang, W. Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai subunits in G-coupled heterotrimeric proteins To be Published, |
Experimental method | X-RAY DIFFRACTION (3.62 Å) |
Structure validation
Download full validation report