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4G5Q

Structure of LGN GL4/Galphai1 complex

Summary for 4G5Q
Entry DOI10.2210/pdb4g5q/pdb
Related4G5O 4G5R 4G5S
DescriptorGuanine nucleotide-binding protein G(i) subunit alpha-1, G-protein-signaling modulator 2, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywordsgalphai, goloco, galpha signaling, asymmetric cell division, cell cycle-signaling protein complex, cell cycle/signaling protein
Biological sourceHomo sapiens (human)
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Cellular locationNucleus (By similarity): P63096
Cytoplasm (By similarity): Q8VDU0
Total number of polymer chains8
Total formula weight167504.22
Authors
Jia, M.,Li, J.,Zhu, J.,Wen, W.,Zhang, M.,Wang, W. (deposition date: 2012-07-18, release date: 2012-09-05, Last modification date: 2024-03-20)
Primary citationJia, M.,Li, J.,Zhu, J.,Wen, W.,Zhang, M.,Wang, W.
Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai subunits in G-coupled heterotrimeric proteins
To be Published,
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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