4G5D
X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH
Summary for 4G5D
| Entry DOI | 10.2210/pdb4g5d/pdb |
| Related | 4F40 |
| Descriptor | Prostaglandin f2-alpha synthase/D-arabinose dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total) |
| Functional Keywords | structural genomics, niaid, national institute of allergy and infectious diseases, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase |
| Biological source | Leishmania major |
| Total number of polymer chains | 2 |
| Total formula weight | 65865.89 |
| Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2012-07-17, release date: 2012-08-15, Last modification date: 2023-09-13) |
| Primary citation | Moen, S.O.,Fairman, J.W.,Barnes, S.R.,Sullivan, A.,Nakazawa-Hewitt, S.,Van Voorhis, W.C.,Staker, B.L.,Lorimer, D.D.,Myler, P.J.,Edwards, T.E. Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP. Acta Crystallogr F Struct Biol Commun, 71:609-614, 2015 Cited by PubMed Abstract: The crystal structures of prostaglandin F synthase (PGF) from both Leishmania major and Trypanosoma cruzi with and without their cofactor NADP have been determined to resolutions of 2.6 Å for T. cruzi PGF, 1.25 Å for T. cruzi PGF with NADP, 1.6 Å for L. major PGF and 1.8 Å for L. major PGF with NADP. These structures were determined by molecular replacement to a final R factor of less than 18.6% (Rfree of less than 22.9%). PGF in the infectious protozoa L. major and T. cruzi is a potential therapeutic target. PubMed: 25945716DOI: 10.1107/S2053230X15006883 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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